Cephalosporin acylase

(Difference between revisions)

Revision as of 09:54, 6 December 2015

Cephalosporin acylase α subunit (grey) and β subunit (green) complex with glutaryl 7-amino-cephalosporanic acid (PDB entry 1jvz)

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Updated on 06-December-2015

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 <StructureSection load='1jvz' size='350' side='right' caption='Cephalosporin acylase α subunit (grey) and β subunit (green) complex with glutaryl 7-amino-cephalosporanic acid (PDB entry [[1jvz]])' scene=''>
-'''Cephalosporin acylase''' (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA).  CSA contains 2 non-identical subunits.  CSA is used commercially for production of semi-synthetic cephalosporin antibiotics.  The active site pocket of CSA is similar to that of penicillin acylase.  CSA precursor is cleaved at 2 sites forming the active heterodimer.
+'''Cephalosporin acylase''' (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA).
+== Relevance ==
+CSA is used commercially for production of semi-synthetic cephalosporin antibiotics.
+== Structural highlights ==
+CSA contains 2 non-identical subunits.  The active site pocket of CSA is similar to that of penicillin acylase.  CSA precursor is cleaved at 2 sites forming the active heterodimer.
 </StructureSection>
 ==3D structures of cephalosporin acylase==