Alanine racemase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Alanine racemase''' (AR) catalyzes the racemization of L-alanine to D-alanine. AR uses pyridoxal-5’-phosphate (PLP) as a cofactor. PLP binds to a lysine residue of AR. AR participates in alanine and aspartate metabolism. <ref>PMID:11886871</ref> | + | '''Alanine racemase''' (AR) catalyzes the racemization of L-alanine to D-alanine. AR uses pyridoxal-5’-phosphate (PLP) as a cofactor. PLP binds to a lysine residue of AR. AR participates in alanine and aspartate metabolism. <ref name="Ad">PMID:11886871</ref> |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | AR uses 2 catalytic bases for the reaction: <scene name='55/551209/Cv/2'>Lys and Tyr</scene> from different monomers.<ref>PMID:11886871</ref> | + | AR uses 2 catalytic bases for the reaction: <scene name='55/551209/Cv/2'>Lys and Tyr</scene> from different monomers.<ref name="Ad">PMID:11886871</ref> |
</StructureSection> | </StructureSection> | ||
Revision as of 11:57, 6 December 2015
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3D Structures of alanine racemase
Updated on 06-December-2015
References
- ↑ 1.0 1.1 Watanabe A, Yoshimura T, Mikami B, Hayashi H, Kagamiyama H, Esaki N. Reaction mechanism of alanine racemase from Bacillus stearothermophilus: x-ray crystallographic studies of the enzyme bound with N-(5'-phosphopyridoxyl)alanine. J Biol Chem. 2002 May 24;277(21):19166-72. Epub 2002 Mar 8. PMID:11886871 doi:10.1074/jbc.M201615200
