Chitinase
From Proteopedia
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| + | <StructureSection load='3wh1' size='350' side='right' caption='Chitinase A complex with (GlcNac)4 (PDB entry [[3wh1]])' scene=''> | ||
| + | __TOC__ | ||
| + | == Function == | ||
[[Chitinase]]s cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. | [[Chitinase]]s cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. | ||
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| + | ==Disease == | ||
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| + | Chi is related to allergies and asthma. | ||
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| + | == Structural highlights == | ||
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| + | The binding site of chitin tetrasaccharide.<ref>PMID:24582745</ref> | ||
| + | </StructureSection> | ||
== 3D Structures of Chitinase == | == 3D Structures of Chitinase == | ||
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**[[2wk2]], [[2wly]], [[2wlz]], [[2wm0]] – SmChi residues 2-520 + inhibitor <br /> | **[[2wk2]], [[2wly]], [[2wlz]], [[2wm0]] – SmChi residues 2-520 + inhibitor <br /> | ||
**[[3g6m]] - BoChi residues 21-426 + caffeine<br /> | **[[3g6m]] - BoChi residues 21-426 + caffeine<br /> | ||
| - | **[[1waw]], [[1wb0]] – hChi catalytic domain | + | **[[1waw]], [[1wb0]] – hChi catalytic domain + polypeptide – human<br /> |
| - | **[[1hkk]], [[1hkm]], [[3rm4]], [[3rm8]], [[3rm9]], [[3rme]] – hChi catalytic domain | + | **[[1hkk]], [[1hkm]], [[3rm4]], [[3rm8]], [[3rm9]], [[3rme]] – hChi catalytic domain + inhibitor<br /> |
**[[1ll4]] - CiChi residues 36-427 + inhibitor<br /> | **[[1ll4]] - CiChi residues 36-427 + inhibitor<br /> | ||
**[[3wl1]], [[3wqv]], [[3wqw]] – cbChi + GlcNAC<br /> | **[[3wl1]], [[3wqv]], [[3wqw]] – cbChi + GlcNAC<br /> | ||
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**[[3w6d]], [[3w6f]] – RaChi catalytic domain (mutant) + polysaccharide<br /> | **[[3w6d]], [[3w6f]] – RaChi catalytic domain (mutant) + polysaccharide<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:32, 7 December 2015
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3D Structures of Chitinase
Updated on 07-December-2015
References
- ↑ Ohnuma T, Umemoto N, Nagata T, Shinya S, Numata T, Taira T, Fukamizo T. Crystal structure of a "loopless" GH19 chitinase in complex with chitin tetrasaccharide spanning the catalytic center. Biochim Biophys Acta. 2014 Feb 25;1844(4):793-802. doi:, 10.1016/j.bbapap.2014.02.013. PMID:24582745 doi:http://dx.doi.org/10.1016/j.bbapap.2014.02.013
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