Cocaine esterase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ||
| + | |||
| + | <StructureSection load='1l7q' size='350' side='right' caption='Cocaine esterase complex with reaction product benzoic acid (PDB entry [[1l7q]])' scene=''> | ||
<!-- | <!-- | ||
| Line 6: | Line 8: | ||
to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
--> | --> | ||
| - | '''Cocaine esterase''' (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse. | ||
| + | == Function == | ||
| + | |||
| + | '''Cocaine esterase''' (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. | ||
| + | |||
| + | == Relevance == | ||
| + | |||
| + | CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse. | ||
| + | </StructureSection> | ||
==3D structures of cocaine esterase== | ==3D structures of cocaine esterase== | ||
| Line 26: | Line 35: | ||
**[[3i2k]] - RhCocE + DTT derivative | **[[3i2k]] - RhCocE + DTT derivative | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 11:58, 8 December 2015
| |||||||||||
3D structures of cocaine esterase
Updated on 08-December-2015
