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Complement C5

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<StructureSection load='3pvm' size='340' side='right' caption='Human complement C5 complex (grey and pink) with cobra venom factor (green and yellow) (PDB code [[3pvm]])' scene=''>
<StructureSection load='3pvm' size='340' side='right' caption='Human complement C5 complex (grey and pink) with cobra venom factor (green and yellow) (PDB code [[3pvm]])' scene=''>
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'''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces '''anaphylatoxin''' which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named '''C345C'''. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex.
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== Function ==
== Function ==
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'''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces '''anaphylatoxin''' which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named '''C345C'''. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex. <ref>PMID:18536718</ref>
== Disease ==
== Disease ==
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Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis and rheumatoid arthritis.
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Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis, Leiner's disease and rheumatoid arthritis.
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== Relevance ==
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== Structural highlights ==
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</StructureSection>
</StructureSection>

Revision as of 07:50, 14 December 2015

Human complement C5 complex (grey and pink) with cobra venom factor (green and yellow) (PDB code 3pvm)

Drag the structure with the mouse to rotate

3D Structures of complement C5

Updated on 14-December-2015

References

  1. ↑ Fredslund F, Laursen NS, Roversi P, Jenner L, Oliveira CL, Pedersen JS, Nunn MA, Lea SM, Discipio R, Sottrup-Jensen L, Andersen GR. Structure of and influence of a tick complement inhibitor on human complement component 5. Nat Immunol. 2008 Jul;9(7):753-60. Epub 2008 Jun 8. PMID:18536718 doi:10.1038/ni.1625

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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