Complement factor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement). | + | '''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement).<ref>PMID:15163532</ref> |
== Disease == | == Disease == | ||
| - | CFH mutations are involved in dense deposit disease, age-related macular degeneration, atypical hemolytic-uremic syndrome and the kidney disorder glomerulonephritis. | + | CFH mutations are involved in dense deposit disease, age-related macular degeneration, atypical hemolytic-uremic syndrome, schizophrenia, stroke and the kidney disorder glomerulonephritis. |
== Relevance == | == Relevance == | ||
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| + | CFH is recruited by human pathogens resulting in increased virulence. | ||
== Structural highlights == | == Structural highlights == | ||
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| + | The sushi domains are ca. 60 amino acid long containing 2 Cys-Cys bonds. | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 09:12, 14 December 2015
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3D structures of complement factor H
Updated on 14-December-2015
References
- ↑ Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sanchez-Corral P. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol. 2004 Jun;41(4):355-67. PMID:15163532 doi:10.1016/j.molimm.2004.02.005
