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Cruzain
From Proteopedia
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| + | <StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene=''> | ||
| - | + | '''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref> | |
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| + | == Relevance == | ||
| + | |||
| + | Cru inhibitors are being investigated for therapeutic use against Chagas disease. | ||
| - | '''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:7707373</ref> | ||
</StructureSection> | </StructureSection> | ||
==3D structures of cruzain== | ==3D structures of cruzain== | ||
Revision as of 11:15, 15 December 2015
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3D structures of cruzain
Updated on 15-December-2015
1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ
