Cruzain

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<StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene=''>
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<StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain complex with methylketone inhibitor (PDB entry [[1me3]])' scene=''>
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'''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref>
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== Relevance ==
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Cru inhibitors are being investigated for therapeutic use against Chagas disease.
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'''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:7707373</ref>
 
</StructureSection>
</StructureSection>
==3D structures of cruzain==
==3D structures of cruzain==

Revision as of 11:15, 15 December 2015

Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry 1me3)

Drag the structure with the mouse to rotate

3D structures of cruzain

Updated on 15-December-2015

1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ

References

  1. ↑ Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15;8(8):831-40. PMID:10997902

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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