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Cyclic GMP-AMP synthase

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<StructureSection load='4k97' size='340' side='right' caption='Structure of mouse cyclic GMP-AMP synthase C terminal complex with DNA, ATP, Mg+2 (green) and Zn+2 (grey) ions (PDB code [[4k97]]). ' scene='59/591942/Cv/1'>
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<StructureSection load='4o67' size='340' side='right' caption='Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code [[4o67]]). ' scene=''>
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== Function ==
== Function ==
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Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.
Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.
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== Structural highlights ==
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The 2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS.
</StructureSection>
</StructureSection>

Revision as of 09:16, 16 December 2015

Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code 4o67).

Drag the structure with the mouse to rotate

3D structures of cyclic GMP-AMP synthase

Updated on 16-December-2015


References

  1. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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