Cytidine monophosphate kinase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='1kdo' size='350' side='right' caption='Structure of ''E. coli'' cytidine monophosphate kinase complex with CMP (stick model) and sulfate (PDB entry [[1kdo]])' scene=''> |
'''Cytidine monophosphate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. <ref>PMID:9862805</ref> | '''Cytidine monophosphate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. <ref>PMID:9862805</ref> | ||
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CMK from bacterial pathogens is a target for new antibiotics development. | CMK from bacterial pathogens is a target for new antibiotics development. | ||
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| + | == Structural highlights == | ||
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| + | CMK active site is highly sugar-specific.<ref>PMID:11827479</ref> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:23, 17 December 2015
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3D structures of cytidine monophosphate kinase
(Updated on 17-December-2015)
References
- ↑ Briozzo P, Golinelli-Pimpaneau B, Gilles AM, Gaucher JF, Burlacu-Miron S, Sakamoto H, Janin J, Barzu O. Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity. Structure. 1998 Dec 15;6(12):1517-27. PMID:9862805
- ↑ Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Barzu O, Gilles AM. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme. J Mol Biol. 2002 Feb 1;315(5):1099-110. PMID:11827479 doi:10.1006/jmbi.2001.5286
