Death-associated protein kinase

Function

Death-associated protein kinase (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions.^[1]

• DAPK1 is a positive mediator of γ-interferon induced programmed cell death.
  
• DAPK2 is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival.
  
• DAPK3 or zipper-interacting protein kinase is involved in the regulation of apoptosis.
  

Relevance

DAPK expression is lost in many types of cancer. DAPK1 expression is elevated in brains of Alzheimer Disease patients.