Death-associated protein kinase
From Proteopedia
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DAPK expression is lost in many types of cancer. DAPK1 expression is elevated in brains of Alzheimer Disease patients. DAPK1 inhibitors are tested as drugs for attenuating acute brain injury. | DAPK expression is lost in many types of cancer. DAPK1 expression is elevated in brains of Alzheimer Disease patients. DAPK1 inhibitors are tested as drugs for attenuating acute brain injury. | ||
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| + | == Structural highlights == | ||
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| + | DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. The ATP substrate is bound in a cleft between the two lobes. <ref>PMID:11573098</ref> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:32, 22 December 2015
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3D structures of death-associated protein kinase
Updated on 22-December-2015
References
- ↑ Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210. PMID:16756490 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142615
- ↑ Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M. Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat Struct Biol. 2001 Oct;8(10):899-907. PMID:11573098 doi:10.1038/nsb1001-899
