Defensin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | |||
<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | <StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | ||
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
| - | '''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system | + | '''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]]. |
== Relevance == | == Relevance == | ||
| Line 13: | Line 12: | ||
Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients. | Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients. | ||
| + | |||
| + | == Structural highlights == | ||
| + | |||
| + | DEF contains 6-8 conserved cysteine residues. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of defensin== | ==3D structures of defensin== | ||
Revision as of 10:07, 22 December 2015
| |||||||||||
3D structures of defensin
Updated on 22-December-2015
