1bc5
From Proteopedia
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|PDB= 1bc5 |SIZE=350|CAPTION= <scene name='initialview01'>1bc5</scene>, resolution 2.2Å | |PDB= 1bc5 |SIZE=350|CAPTION= <scene name='initialview01'>1bc5</scene>, resolution 2.2Å | ||
|SITE= <scene name='pdbsite=COB:Co+Binding+Site+Is+Formed+By+HIS+192+And+HIS+114+Of+Symm+...'>COB</scene> | |SITE= <scene name='pdbsite=COB:Co+Binding+Site+Is+Formed+By+HIS+192+And+HIS+114+Of+Symm+...'>COB</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Protein-glutamate_O-methyltransferase Protein-glutamate O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.80 2.1.1.80] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-glutamate_O-methyltransferase Protein-glutamate O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.80 2.1.1.80] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bc5 OCA], [http://www.ebi.ac.uk/pdbsum/1bc5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bc5 RCSB]</span> | ||
}} | }} | ||
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[[Category: Djordjevic, S.]] | [[Category: Djordjevic, S.]] | ||
[[Category: Stock, A M.]] | [[Category: Stock, A M.]] | ||
| - | [[Category: ACE]] | ||
| - | [[Category: CO]] | ||
| - | [[Category: SAH]] | ||
[[Category: chemotaxis receptor]] | [[Category: chemotaxis receptor]] | ||
[[Category: complex (methyltransferase/peptide)]] | [[Category: complex (methyltransferase/peptide)]] | ||
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[[Category: peptide binding]] | [[Category: peptide binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:57:58 2008'' |
Revision as of 15:58, 30 March 2008
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| , resolution 2.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Protein-glutamate O-methyltransferase, with EC number 2.1.1.80 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CHEMOTAXIS RECEPTOR RECOGNITION BY PROTEIN METHYLTRANSFERASE CHER
Overview
Signal transduction processes commonly involve reversible covalent modifications of receptors. Bacterial chemotaxis receptors are reversibly methylated at specific glutamate residues within coiled-coil regions of their cytoplasmic domains. Methylation is catalyzed by an S-adenosylmethionine-dependent protein methyltransferase, CheR, that binds to a specific sequence at the C-termini of some chemotaxis receptors. From this tethering point, CheR methylates neighboring receptor molecules. We report the crystal structure, determined to 2.2 A resolution, of a complex of the Salmonella typhimurium methyltransferase CheR bound to the methylation reaction product, S-adenosylhomocysteine (AdoHcy), and the C-terminal pentapeptide of the aspartate receptor, Tar. The structure indicates the basis for the specificity of interaction between the chemoreceptors and CheR and identifies a specific receptor binding motif incorporated in the CheR methyltransferase domain.
About this Structure
1BC5 is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.
Reference
Chemotaxis receptor recognition by protein methyltransferase CheR., Djordjevic S, Stock AM, Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:9628482
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