DNA methyltransferase
From Proteopedia
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The human ICF disorder is caused by mutations in DNMT 3B. | The human ICF disorder is caused by mutations in DNMT 3B. | ||
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| + | == Structural highlights == | ||
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| + | The active site of methyladenine DNMT contains the methyl donor SAM. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of DNA methyltransferase == | == 3D Structures of DNA methyltransferase == | ||
Revision as of 14:36, 31 December 2015
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3D Structures of DNA methyltransferase
Updated on 31-December-2015
References
- ↑ Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
- ↑ Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
- ↑ Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
