This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
DnaA
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_1j1v| PDB=1j1v | SIZE=400| SCENE= |right|CAPTION= E. coli DnaA complex with DNA [[1j1v]] }} | {{STRUCTURE_1j1v| PDB=1j1v | SIZE=400| SCENE= |right|CAPTION= E. coli DnaA complex with DNA [[1j1v]] }} | ||
| - | '''DnaA''' activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref> For more details see [[Molecular Playground/DNA replication initiator DnaA]]. | + | '''DnaA''' activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref> |
| + | For more details see [[Molecular Playground/DNA replication initiator DnaA]]. | ||
==3D structures of DnaA== | ==3D structures of DnaA== | ||
Revision as of 12:36, 3 January 2016
DnaA activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). [1] For more details see Molecular Playground/DNA replication initiator DnaA.
3D structures of DnaA
Updated on 03-January-2016
1l8q – AaDnaA + ADP – Aquifex aeolicus
2hcb - AaDnaA + AMPPCP
3r8f - AaDnaA DNA binding domain + DNA
1j1v – EcDnaA DNA binding domain + DNA – Escherichia coli
2e0g - EcDnaA N terminal – NMR
2jmp - DnaA N terminal – Mycoplasma genitalium – NMR
2z4r, 2z4s - DnaA domain III – Thermotoga maritima
2wp0 - DnaA N terminal + HOBA – Helicobacter pylori
3pvp, 3pvv - DnaA DNA binding domain + DNA – Mycobacterium tuberculosis
References
- ↑ Mott ML, Berger JM. DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol. 2007 May;5(5):343-54. PMID:17435790 doi:http://dx.doi.org/10.1038/nrmicro1640
