7,8-dihydro-8-oxoguanine triphosphatase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3zr0' size='350' side='right' caption='Structure of human MTH1 complex with 8-oxo-dGTP | + | <StructureSection load='3zr0' size='350' side='right' caption='Structure of human MTH1 complex with 8-oxo-dGTP and sulfate (PDB code [[3zr0]]).' scene='59/597008/Cv/1'> |
== Function == | == Function == | ||
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The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA. | The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA. | ||
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| + | == Structural highlights == | ||
| + | *<scene name='59/597008/Cv/3'>Active site</scene> of DGTP. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 12:34, 6 January 2016
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3D structures of 7,8-dihydro-8-oxoguanine triphosphatase
Updated on 06-January-2016
References
- ↑ Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y. Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J Biol Chem. 2010 Jan 1;285(1):444-52. Epub 2009 Oct 28. PMID:19864691 doi:10.1074/jbc.M109.066373
