Elastase
From Proteopedia
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{{STRUCTURE_1esa| PDB=1esa | SIZE=400| SCENE= |right|CAPTION= Pig elastase acyl-intermediate complex with sulfate and Ca+2 ion [[1esa]] }} | {{STRUCTURE_1esa| PDB=1esa | SIZE=400| SCENE= |right|CAPTION= Pig elastase acyl-intermediate complex with sulfate and Ca+2 ion [[1esa]] }} | ||
- | [[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. | + | [[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]]. |
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+ | == Relevance == | ||
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+ | '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation. | ||
== Disease == | == Disease == |
Revision as of 11:38, 11 January 2016
Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. [1] For additional details see Serine Proteases.
Contents |
Relevance
ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.
Disease
Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid.
3D structures of elastase
Updated on 11-January-2016
References
- ↑ Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002 Apr;40(4):325-32. PMID:12059069 doi:http://dx.doi.org/10.1515/CCLM.2002.051
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Guido Hansen, Jaime Prilusky