Elastase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_1esa| PDB=1esa | SIZE=400| SCENE= |right|CAPTION= Pig elastase acyl-intermediate complex with sulfate and Ca+2 ion [[1esa]] }}
{{STRUCTURE_1esa| PDB=1esa | SIZE=400| SCENE= |right|CAPTION= Pig elastase acyl-intermediate complex with sulfate and Ca+2 ion [[1esa]] }}
-
[[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.<ref>PMID:12059069</ref> For additional details see [[Serine Proteases]].
+
[[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]].
 +
 
 +
== Relevance ==
 +
 
 +
'''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
== Disease ==
== Disease ==

Revision as of 11:38, 11 January 2016

Template:STRUCTURE 1esa

Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. [1] For additional details see Serine Proteases.

Contents

Relevance

ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.

Disease

Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid.

3D structures of elastase

Updated on 11-January-2016

References

  1. Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002 Apr;40(4):325-32. PMID:12059069 doi:http://dx.doi.org/10.1515/CCLM.2002.051

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Guido Hansen, Jaime Prilusky

Personal tools