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4zh8

From Proteopedia

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m (Protected "4zh8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Factor Xa complex with GTC000006==
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<StructureSection load='4zh8' size='340' side='right' caption='[[4zh8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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The entry 4zh8 is ON HOLD until Oct 24 2016
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zh8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZH8 FirstGlance]. <br>
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Authors: Convery, M.A.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4O4:6-CHLORO-N-{(3S)-1-[(2S)-1-(MORPHOLIN-4-YL)-1-OXOPROPAN-2-YL]-2-OXO-2,3-DIHYDRO-1H-PYRROL-3-YL}-N-(2-OXOBUTYL)NAPHTHALENE-2-SULFONAMIDE'>4O4</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
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Description: Factor Xa complex with GTC000006
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zh8 OCA], [http://pdbe.org/4zh8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zh8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zh8 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Convery, M.A]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Coagulation factor Xa]]
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[[Category: Homo sapiens]]
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[[Category: Convery, M A]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]

Revision as of 20:25, 13 January 2016

Factor Xa complex with GTC000006

4zh8, resolution 1.80Å

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