Catabolite gene activator protein
From Proteopedia
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| - | <StructureSection load='1o3r' size='350' side='right' scene='54/543372/Cv/3' caption='Catabolite gene activator protein complex with cAMP | + | <StructureSection load='1o3r' size='350' side='right' scene='54/543372/Cv/3' caption='Catabolite gene activator protein complex with cAMP and DNA ([[1o3r]])'> |
'''Catabolite gene activator protein''' (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. <scene name='54/543372/Cv/4'>Four cAMP molecules bind to the dimeric CAP</scene>. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. <ref>PMID:10550204</ref> | '''Catabolite gene activator protein''' (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. <scene name='54/543372/Cv/4'>Four cAMP molecules bind to the dimeric CAP</scene>. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. <ref>PMID:10550204</ref> | ||
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<scene name='54/543372/Cv/6'>1st cAMP binding site</scene> | <scene name='54/543372/Cv/6'>1st cAMP binding site</scene> | ||
| - | + | <scene name='54/543372/Cv/8'>2nd cAMP binding site</scene> | |
</StructureSection> | </StructureSection> | ||
Revision as of 10:23, 17 January 2016
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3D Structures of catabolite gene activator protein
Updated on 17-January-2016
References
- ↑ Busby S, Ebright RH. Transcription activation by catabolite activator protein (CAP). J Mol Biol. 1999 Oct 22;293(2):199-213. PMID:10550204 doi:http://dx.doi.org/10.1006/jmbi.1999.3161
