Erythropoietin receptor
From Proteopedia
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<StructureSection load='1cn4' size='340' side='right' caption='Human erythropoietin receptor (grey and green) complex with erythropoietin (pink) (PDB code [[1cn4]])' scene=''> | <StructureSection load='1cn4' size='340' side='right' caption='Human erythropoietin receptor (grey and green) complex with erythropoietin (pink) (PDB code [[1cn4]])' scene=''> | ||
| - | '''Erythropoietin receptor''' (EpoR) is a cytokine receptor. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. This change induces the activation of Jak2 kinase via its autophophorylation. Specific tyrosines in the intracellular part of EpoR are phosphorylated and activate various cascades of signal transduction which lead to the formation and maturation of red blood cells. | ||
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== Function == | == Function == | ||
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| + | '''Erythropoietin receptor''' (EpoR) is a cytokine receptor. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. This change induces the activation of Jak2 kinase via its autophophorylation. Specific tyrosines in the intracellular part of EpoR are phosphorylated and activate various cascades of signal transduction which lead to the formation and maturation of red blood cells<ref>PMID:8481505</ref>. | ||
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| + | == Relevance == | ||
EpoR rescues red blood cells progenitors from apoptosis. | EpoR rescues red blood cells progenitors from apoptosis. | ||
== Disease == | == Disease == | ||
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| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 14:39, 20 January 2016
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3D Structures of erythropoietin receptor
Updated on 20-January-2016
1ern – hEpoR extracellular domain - human
2mv6 – hEpoR transmembrane domain - NMR
1ebp, 1eba – hEpoR extracellular domain + Epo peptide
1cn4, 1eer – hEpoR extracellular domain (mutant) + Epo (mutant)
2jix – hEpoR extracellular domain + antibody
4y5x, 4y5v – hEpoR extracellular domain + diabody
References
- ↑ Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF. Structure, function, and activation of the erythropoietin receptor. Blood. 1993 May 1;81(9):2223-36. PMID:8481505
