1bqo

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|PDB= 1bqo |SIZE=350|CAPTION= <scene name='initialview01'>1bqo</scene>, resolution 2.3&Aring;
|PDB= 1bqo |SIZE=350|CAPTION= <scene name='initialview01'>1bqo</scene>, resolution 2.3&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=N25:1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC ACID HYDROXYAMIDE'>N25</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=N25:1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC+ACID+HYDROXYAMIDE'>N25</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span>
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqo OCA], [http://www.ebi.ac.uk/pdbsum/1bqo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bqo RCSB]</span>
}}
}}
'''DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS'''
'''DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS'''
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==Disease==
 
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Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=185250 185250]]
 
==About this Structure==
==About this Structure==
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[[Category: Snider, C E.]]
[[Category: Snider, C E.]]
[[Category: Taiwo, Y O.]]
[[Category: Taiwo, Y O.]]
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[[Category: CA]]
 
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[[Category: N25]]
 
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[[Category: ZN]]
 
[[Category: matrix metalloprotease]]
[[Category: matrix metalloprotease]]
[[Category: osteoarthritis]]
[[Category: osteoarthritis]]
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[[Category: structure-based drug design]]
[[Category: structure-based drug design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:14:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:06:18 2008''

Revision as of 16:06, 30 March 2008


PDB ID 1bqo

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands: , ,
Activity: Stromelysin 1, with EC number 3.4.24.17
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS


About this Structure

1BQO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of potent, achiral matrix metalloproteinase inhibitors., Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE, J Med Chem. 1998 Sep 10;41(19):3568-71. PMID:9733482

Page seeded by OCA on Sun Mar 30 19:06:18 2008

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