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4xja
From Proteopedia
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| - | + | ==Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid== | |
| - | + | <StructureSection load='4xja' size='340' side='right' caption='[[4xja]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xja]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=OPX:(1S,3R,4S)-1-[(CYCLOHEXYLAMINO)METHYL]-3,4-DIHYDROXYCYCLOPENTANESULFONIC+ACID'>OPX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SFJ:(2R,3R,4R,5R,6R)-5-(ACETYLAMINO)-2,3-DIFLUORO-4-HYDROXY-6-[(1R,2R)-1,2,3-TRIHYDROXYPROPYL]TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC+ACID'>SFJ</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xja OCA], [http://pdbe.org/4xja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xja RCSB], [http://www.ebi.ac.uk/pdbsum/4xja PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Exo-alpha-sialidase]] | ||
[[Category: Brear, P]] | [[Category: Brear, P]] | ||
| + | [[Category: Allosteric inhibitor]] | ||
| + | [[Category: Crystallization artefact]] | ||
| + | [[Category: Drug design]] | ||
| + | [[Category: Glycosidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Intramolecular trans-sialidase]] | ||
| + | [[Category: Neuraminidase]] | ||
| + | [[Category: Serendipitous allosteric site]] | ||
Revision as of 17:13, 20 January 2016
Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
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