Factor VIII

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{{STRUCTURE_2r7e| PDB=2r7e | SIZE=400| SCENE=Factor_VIII/Cv/1 |right|CAPTION=Glycosylated human Factor VIII. Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions, [[2r7e]] }}
 
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[[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for [[Factor IX|factor IXa]]. See also [[Factor VIII (Hebrew)]].
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<StructureSection load='2r7e' size='350' side='right' scene='' caption='Glycosylated human Factor VIII. Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code [[2r7e]]) '>
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== Function ==
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[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].
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The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the
The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.-->
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.-->
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== Disease ==
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Defects in the protein result in hemophilia A.
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== Relevance ==
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Factor VIII is given to hemophiliacs in order to restore homestasis.
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</StructureSection>
== 3D Structures of Factor VIII ==
== 3D Structures of Factor VIII ==

Revision as of 20:26, 20 January 2016

Glycosylated human Factor VIII. Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e)

Drag the structure with the mouse to rotate

3D Structures of Factor VIII

Updated on 20-January-2016

2r7e, 3cdz, 3j2q, 4bdv – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse
3j2s - hFVIII light chain
4mo3 - FVIII light chain C2 domain – pig

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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