Farnesyltransferase

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== Relevance ==
== Relevance ==
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FTase inhibitors are being tested as anti-cancer agents.
+
FTase inhibitors are being tested as anti-cancer and anti-Progeria agents.
== Structural insights ==
== Structural insights ==

Revision as of 14:46, 21 January 2016

Farnesyltransferase α subunit (grey) and β subunit (green) complex with farnesyl diphosphate (FPP) analog, Zn+2 ion (grey), sulfonic acid derivative and CAAX peptide (pink) (PDB code 3q75)

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3D structures of farnesyltransferase

Updated on 21-January-2016

References

  1. ↑ Reid TS, Terry KL, Casey PJ, Beese LS. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. 2004 Oct 15;343(2):417-33. PMID:15451670 doi:10.1016/j.jmb.2004.08.056
  2. ↑ Hast MA, Nichols CB, Armstrong SM, Kelly SM, Hellinga HW, Alspaugh JA, Beese LS. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J Biol Chem. 2011 Oct 7;286(40):35149-62. Epub 2011 Aug 4. PMID:21816822 doi:10.1074/jbc.M111.250506

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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