Farnesyltransferase
From Proteopedia
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== Structural insights == | == Structural insights == | ||
| - | FTase are composed of 2 subunits. <scene name='48/485616/Cv/5'>α subunit</scene> is in cyan, <scene name='48/485616/Cv/4'>β subunit</scene> is in green. <scene name='48/485616/Cv/6'>CAAX peptide and ligands</scene>. The <scene name='48/485616/Cv/9'>CAAX motif and β subunit coordinate with the Zn+2 ion</scene> and the <scene name='48/485616/Cv/10'>FPP predominantly coordinates with the β subunit</scene><ref>PMID:21816822</ref>. | + | FTase are composed of 2 subunits. <scene name='48/485616/Cv/5'>α subunit</scene> is in cyan, <scene name='48/485616/Cv/4'>β subunit</scene> is in green. <scene name='48/485616/Cv/6'>CAAX peptide and ligands</scene>. The <scene name='48/485616/Cv/9'>CAAX motif and β subunit coordinate with the Zn+2 ion</scene> and the <scene name='48/485616/Cv/10'>FPP predominantly coordinates with the β subunit</scene><ref>PMID:21816822</ref>. Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
==3D structures of farnesyltransferase== | ==3D structures of farnesyltransferase== | ||
Revision as of 10:49, 25 January 2016
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3D structures of farnesyltransferase
Updated on 25-January-2016
References
- ↑ Reid TS, Terry KL, Casey PJ, Beese LS. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. 2004 Oct 15;343(2):417-33. PMID:15451670 doi:10.1016/j.jmb.2004.08.056
- ↑ Hast MA, Nichols CB, Armstrong SM, Kelly SM, Hellinga HW, Alspaugh JA, Beese LS. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J Biol Chem. 2011 Oct 7;286(40):35149-62. Epub 2011 Aug 4. PMID:21816822 doi:10.1074/jbc.M111.250506
