1c8z
From Proteopedia
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|PDB= 1c8z |SIZE=350|CAPTION= <scene name='initialview01'>1c8z</scene>, resolution 1.9Å | |PDB= 1c8z |SIZE=350|CAPTION= <scene name='initialview01'>1c8z</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8z OCA], [http://www.ebi.ac.uk/pdbsum/1c8z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c8z RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Myers, S C.]] | [[Category: Myers, S C.]] | ||
[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
| - | [[Category: PO4]] | ||
[[Category: 12-stranded-beta-barrel]] | [[Category: 12-stranded-beta-barrel]] | ||
[[Category: beta-barrel]] | [[Category: beta-barrel]] | ||
| Line 34: | Line 36: | ||
[[Category: tubby filled-barrel]] | [[Category: tubby filled-barrel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:01 2008'' |
Revision as of 16:17, 30 March 2008
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| , resolution 1.9Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN
Overview
Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
About this Structure
1C8Z is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637
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