1d0b
From Proteopedia
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|PDB= 1d0b |SIZE=350|CAPTION= <scene name='initialview01'>1d0b</scene>, resolution 1.86Å | |PDB= 1d0b |SIZE=350|CAPTION= <scene name='initialview01'>1d0b</scene>, resolution 1.86Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d0b OCA], [http://www.ebi.ac.uk/pdbsum/1d0b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d0b RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Ghosh, P.]] | [[Category: Ghosh, P.]] | ||
[[Category: Marino, M.]] | [[Category: Marino, M.]] | ||
| - | [[Category: CA]] | ||
[[Category: calcium binding]] | [[Category: calcium binding]] | ||
[[Category: leucine rich repeat]] | [[Category: leucine rich repeat]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:32:05 2008'' |
Revision as of 16:32, 30 March 2008
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| , resolution 1.86Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
INTERNALIN B LEUCINE RICH REPEAT DOMAIN
Overview
The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.
About this Structure
1D0B is a Single protein structure of sequence from Listeria monocytogenes. Full crystallographic information is available from OCA.
Reference
Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes., Marino M, Braun L, Cossart P, Ghosh P, Mol Cell. 1999 Dec;4(6):1063-72. PMID:10635330
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