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1da2
From Proteopedia
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|PDB= 1da2 |SIZE=350|CAPTION= <scene name='initialview01'>1da2</scene>, resolution 1.700Å | |PDB= 1da2 |SIZE=350|CAPTION= <scene name='initialview01'>1da2</scene>, resolution 1.700Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=C45:N4-METHOXY-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE'>C45</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1da2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1da2 OCA], [http://www.ebi.ac.uk/pdbsum/1da2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1da2 RCSB]</span> | ||
}} | }} | ||
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[[Category: z-dna]] | [[Category: z-dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:37:37 2008'' |
Revision as of 16:37, 30 March 2008
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| , resolution 1.700Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA
Overview
The base analogue N4-methoxycytosine (mo4C) is ambivalent in its hydrogen-bonding potential, since it forms stable base-pairs with both adenine and guanine in oligomer duplexes. To investigate the base-pair geometry, the structure of d(CGCGmo4CG) has been determined by single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2 crystallized in a left-handed double helical structure (Z-type). Refinement using 2559 reflections between 10 and 1.7 A converged with a final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is of the wobble type, with mo4C in the imino form, and the methoxy group in the syn configuration.
About this Structure
1DA2 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:2258939
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