2cli

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<StructureSection load='2cli' size='340' side='right' caption='[[2cli]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2cli' size='340' side='right' caption='[[2cli]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cli]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CLI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cli]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CLI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9F:2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL+DIHYDROGEN+PHOSPHATE'>F9F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F9F:2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL+DIHYDROGEN+PHOSPHATE'>F9F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a50|1a50]], [[1a5a|1a5a]], [[1a5b|1a5b]], [[1a5s|1a5s]], [[1bks|1bks]], [[1c29|1c29]], [[1c8v|1c8v]], [[1c9d|1c9d]], [[1cw2|1cw2]], [[1cx9|1cx9]], [[1fuy|1fuy]], [[1geq|1geq]], [[1k3u|1k3u]], [[1k7e|1k7e]], [[1k7f|1k7f]], [[1k7x|1k7x]], [[1k8y|1k8y]], [[1k8z|1k8z]], [[1kfj|1kfj]], [[1kfk|1kfk]], [[1qop|1qop]], [[1qoq|1qoq]], [[1rd5|1rd5]], [[1tjp|1tjp]], [[1ttp|1ttp]], [[1ttq|1ttq]], [[1ubs|1ubs]], [[1ujp|1ujp]], [[1v7y|1v7y]], [[1v8z|1v8z]], [[1wbj|1wbj]], [[1wq5|1wq5]], [[1wxj|1wxj]], [[1xc4|1xc4]], [[1xcf|1xcf]], [[2cle|2cle]], [[2clf|2clf]], [[2clh|2clh]], [[2clk|2clk]], [[2cll|2cll]], [[2clm|2clm]], [[2clo|2clo]], [[2trs|2trs]], [[2tsy|2tsy]], [[2tys|2tys]], [[2wsy|2wsy]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a50|1a50]], [[1a5a|1a5a]], [[1a5b|1a5b]], [[1a5s|1a5s]], [[1bks|1bks]], [[1c29|1c29]], [[1c8v|1c8v]], [[1c9d|1c9d]], [[1cw2|1cw2]], [[1cx9|1cx9]], [[1fuy|1fuy]], [[1geq|1geq]], [[1k3u|1k3u]], [[1k7e|1k7e]], [[1k7f|1k7f]], [[1k7x|1k7x]], [[1k8y|1k8y]], [[1k8z|1k8z]], [[1kfj|1kfj]], [[1kfk|1kfk]], [[1qop|1qop]], [[1qoq|1qoq]], [[1rd5|1rd5]], [[1tjp|1tjp]], [[1ttp|1ttp]], [[1ttq|1ttq]], [[1ubs|1ubs]], [[1ujp|1ujp]], [[1v7y|1v7y]], [[1v8z|1v8z]], [[1wbj|1wbj]], [[1wq5|1wq5]], [[1wxj|1wxj]], [[1xc4|1xc4]], [[1xcf|1xcf]], [[2cle|2cle]], [[2clf|2clf]], [[2clh|2clh]], [[2clk|2clk]], [[2cll|2cll]], [[2clm|2clm]], [[2clo|2clo]], [[2trs|2trs]], [[2tsy|2tsy]], [[2tys|2tys]], [[2wsy|2wsy]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cli RCSB], [http://www.ebi.ac.uk/pdbsum/2cli PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cli OCA], [http://pdbe.org/2cli PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cli RCSB], [http://www.ebi.ac.uk/pdbsum/2cli PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cli ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2cli" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
 
[[Category: Tryptophan synthase]]
[[Category: Tryptophan synthase]]
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[[Category: Barends, T R.]]
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[[Category: Barends, T R]]
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[[Category: Blumenstein, L.]]
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[[Category: Blumenstein, L]]
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[[Category: Casino, P.]]
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[[Category: Casino, P]]
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[[Category: Dunn, M F.]]
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[[Category: Dunn, M F]]
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[[Category: Harris, R.]]
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[[Category: Harris, R]]
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[[Category: Kimmich, N.]]
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[[Category: Kimmich, N]]
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[[Category: Kulik, V.]]
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[[Category: Kulik, V]]
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[[Category: Ngo, H.]]
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[[Category: Ngo, H]]
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[[Category: Niks, D.]]
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[[Category: Niks, D]]
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[[Category: Schlichting, I.]]
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[[Category: Schlichting, I]]
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[[Category: Weyand, M.]]
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[[Category: Weyand, M]]
[[Category: Allosteric enzyme]]
[[Category: Allosteric enzyme]]
[[Category: Amino-acid biosynthesis]]
[[Category: Amino-acid biosynthesis]]

Current revision

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE (F9)

2cli, resolution 1.70Å

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