1dth
From Proteopedia
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|PDB= 1dth |SIZE=350|CAPTION= <scene name='initialview01'>1dth</scene>, resolution 2.0Å | |PDB= 1dth |SIZE=350|CAPTION= <scene name='initialview01'>1dth</scene>, resolution 2.0Å | ||
|SITE= <scene name='pdbsite=CAA:Ca+Ion+Binding+Site'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Ion+Binding+Site'>CAB</scene>, <scene name='pdbsite=ZNA:Zn+Binding+Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene> | |SITE= <scene name='pdbsite=CAA:Ca+Ion+Binding+Site'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Ion+Binding+Site'>CAB</scene>, <scene name='pdbsite=ZNA:Zn+Binding+Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dth OCA], [http://www.ebi.ac.uk/pdbsum/1dth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dth RCSB]</span> | ||
}} | }} | ||
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[[Category: Scapozza, L.]] | [[Category: Scapozza, L.]] | ||
[[Category: Zhang, D.]] | [[Category: Zhang, D.]] | ||
| - | [[Category: BAT]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: ZN]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:48:18 2008'' |
Revision as of 16:48, 30 March 2008
| |||||||
| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , and | ||||||
| Ligands: | , , | ||||||
| Activity: | Atrolysin C, with EC number 3.4.24.42 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
METALLOPROTEASE
Overview
Matrix metalloproteinase enzymes have been implicated in degenerative processes like tumor cell invasion, metastasis, and arthritis. Specific metalloproteinase inhibitors have been used to block tumor cell proliferation. We have examined the interaction of batimastat (BB-94) with a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. This unprecedented binding geometry dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor drugs.
About this Structure
1DTH is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.
Reference
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding., Botos I, Scapozza L, Zhang D, Liotta LA, Meyer EF, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. PMID:8610113
Page seeded by OCA on Sun Mar 30 19:48:18 2008
Categories: Atrolysin C | Crotalus atrox | Single protein | Botos, I. | Liotta, L A. | Meyer, E F. | Scapozza, L. | Zhang, D. | Hydrolase | Metalloprotease | Venom | Zinc
