1f2r
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1c9f|1C9F]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2r OCA], [http://www.ebi.ac.uk/pdbsum/1f2r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f2r RCSB]</span> | ||
}} | }} | ||
| Line 30: | Line 33: | ||
[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:14:36 2008'' |
Revision as of 17:14, 30 March 2008
| |||||||
| Related: | 1C9F
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR STRUCTURE OF THE HETERODIMERIC COMPLEX BETWEEN CAD DOMAINS OF CAD AND ICAD
Overview
We present here the structure of the complex between the CAD domain of caspase activated deoxyribonuclease (CAD) and the CAD domain of its inhibitor (ICAD), determined by nuclear magnetic resonance spectroscopy. The two domains adopt a very similar fold, which consists of an alpha-helix and a beta-sheet, and are aligned side by side in the complex. Notably, the positive charges on the strand beta2 at one end of the beta-sheet of CAD and negative charges around the opposite end of the beta-sheet of ICAD are paired in the complex. Point mutations of the charged amino acids at this interface, on either CAD or ICAD, prevented formation of the functional CAD-ICAD complex. This implies that the interaction between the CAD domains of CAD and ICAD is an essential step in the correct folding of CAD in the complex.
About this Structure
1F2R is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of the heterodimeric complex between CAD domains of CAD and ICAD., Otomo T, Sakahira H, Uegaki K, Nagata S, Yamazaki T, Nat Struct Biol. 2000 Aug;7(8):658-62. PMID:10932250
Page seeded by OCA on Sun Mar 30 20:14:36 2008
