This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5dg6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor==
-
 
+
<StructureSection load='5dg6' size='340' side='right' caption='[[5dg6]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-
The entry 5dg6 is ON HOLD until Paper Publication
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5dg6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DG6 FirstGlance]. <br>
-
Authors: Lovell, S., Battaile, K.P., Mehzabeen, N., Damalanka, V.C., Kim, Y., Alliston, K.R., Weerawarna, P.M., Kankanamalage, A.C.G., Lushington, G.H., Chang, K.-O., Groutas, W.C.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=V66:TERT-BUTYL+[(4S,7S,10S)-7-(CYCLOHEXYLMETHYL)-10-(HYDROXYMETHYL)-5,8,13-TRIOXO-23-OXA-6,9,14,21,22-PENTAAZABICYCLO[18.2.1]TRICOSA-1(22),20-DIEN-4-YL]CARBAMATE'>V66</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dgj|5dgj]]</td></tr>
-
Description: 2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calicivirin Calicivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.66 3.4.22.66] </span></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dg6 OCA], [http://pdbe.org/5dg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/5dg6 PDBsum]</span></td></tr>
-
[[Category: Battaile, K.P]]
+
</table>
-
[[Category: Weerawarna, P.M]]
+
== Function ==
-
[[Category: Alliston, K.R]]
+
[[http://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68]] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Calicivirin]]
 +
[[Category: Alliston, K R]]
 +
[[Category: Battaile, K P]]
 +
[[Category: Chang, K O]]
 +
[[Category: Damalanka, V C]]
 +
[[Category: Groutas, W C]]
 +
[[Category: Kankanamalage, A C.G]]
 +
[[Category: Kim, Y]]
[[Category: Lovell, S]]
[[Category: Lovell, S]]
-
[[Category: Lushington, G.H]]
+
[[Category: Lushington, G H]]
-
[[Category: Chang, K.-O]]
+
-
[[Category: Damalanka, V.C]]
+
-
[[Category: Groutas, W.C]]
+
[[Category: Mehzabeen, N]]
[[Category: Mehzabeen, N]]
-
[[Category: Kankanamalage, A.C.G]]
+
[[Category: Weerawarna, P M]]
-
[[Category: Kim, Y]]
+
[[Category: Antiviral inhibitor]]
 +
[[Category: Cell permeable]]
 +
[[Category: Hydrolase-hydrolase inhibitor complex]]
 +
[[Category: Norovirus]]
 +
[[Category: Norwalk virus]]
 +
[[Category: Oxadiazole inhibitor]]
 +
[[Category: Protease]]

Revision as of 17:25, 10 February 2016

2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor

5dg6, resolution 2.35Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5dg6"
Personal tools