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5i3l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==DPF3b in complex with H3K14ac peptide== | |
| - | + | <StructureSection load='5i3l' size='340' side='right' caption='[[5i3l]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i3l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3l OCA], [http://pdbe.org/5i3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3l RCSB], [http://www.ebi.ac.uk/pdbsum/5i3l PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DPF3_HUMAN DPF3_HUMAN]] Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.<ref>PMID:18765789</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Liu, Y]] | ||
| + | [[Category: Loppnau, P]] | ||
| + | [[Category: Min, J]] | ||
[[Category: Qin, S]] | [[Category: Qin, S]] | ||
| - | [[Category: Structural | + | [[Category: Structural genomic]] |
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| - | + | ||
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[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| - | [[Category: | + | [[Category: Walker, J R]] |
| - | + | ||
[[Category: Zhao, A]] | [[Category: Zhao, A]] | ||
| - | [[Category: | + | [[Category: Peptide binding protein]] |
| + | [[Category: Sgc]] | ||
Revision as of 18:23, 26 February 2016
DPF3b in complex with H3K14ac peptide
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Categories: Arrowsmith, C H | Bountra, C | Edwards, A M | Liu, Y | Loppnau, P | Min, J | Qin, S | Structural genomic | Tempel, W | Walker, J R | Zhao, A | Peptide binding protein | Sgc
