Sandbox Wabash 23 Fumarase
From Proteopedia
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| - | ==Fumarase== | + | ==Determination of the active site Fumarase== |
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | + | Benjamin Washer | |
This is a default text for your page '''Sandbox Wabash 23 Fumarase'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Sandbox Wabash 23 Fumarase'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| + | Fumarase C is an enzyme found in ''E. coli'' (EfumC) that is similar to the cytosolic sand mitochondrial enzymes found in eukaryotic cells and is used to catalyze the hydration/dehydration reaction between L-malate and fumarate. Because of its relative simplicity, homology with important eukaryotic enzymes and important metabolic influence, fumarase has been the object of much study. However, upon analysis of fumarase, it was found that there were two "active" sites and much debate has arisen regarding which is the most influential or "true" one. This article describes the debate and the process used to determine the true active site. | ||
| - | == Disease == | ||
== Relevance == | == Relevance == | ||
Revision as of 21:41, 29 February 2016
Determination of the active site Fumarase
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
