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Fructokinase

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{{STRUCTURE_3lki| PDB=3lki | SIZE=400| SCENE= |right|CAPTION=Se-Met fructokinase dimer complex with ATP (stick model), phosphate and K+ ion (purple), [[3lki]] }}
{{STRUCTURE_3lki| PDB=3lki | SIZE=400| SCENE= |right|CAPTION=Se-Met fructokinase dimer complex with ATP (stick model), phosphate and K+ ion (purple), [[3lki]] }}
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== Function ==
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'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>.
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== Relevance ==
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Inhibitors of FRK C may block sugar-associated metabolic syndromes.
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'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors.
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== Disease ==
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FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria<ref>PMID:2992452</ref>.
==3D structures of fructokinase==
==3D structures of fructokinase==
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[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br />
[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br />
[[3c8u]] – FRK – ''Silicibacter''<br />
[[3c8u]] – FRK – ''Silicibacter''<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:03, 2 March 2016

Template:STRUCTURE 3lki

Contents

Function

Fructokinase (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors[1].

Relevance

Inhibitors of FRK C may block sugar-associated metabolic syndromes.

Disease

FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria[2].

3D structures of fructokinase

Updated on 02-March-2016

2qhp – FRK – Bacterioides thetaiotamicron
3ljs – XfFRK – Xylella fastidiosa
3hj6 – FRK – Halothermothrix orenii
3lki – XfFRK + ATP
3lm9 - BsFRK + ATP + fructose – Bacillus subtilis
3ohr - BsFRK + ADP
2v78, 2var – FRK – Sulfolobus solfataricus
3c8u – FRK – Silicibacter

References

  1. ↑ James HM, Williams SG, Bais R, Rofe AM, Edwards JB, Conyers RA. The metabolic production of oxalate from xylitol: activities of transketolase, transaldolase, fructokinase and aldolase in liver, kidney, brain, heart and muscle in the rat, mouse, guinea pig, rabbit and human. Int J Vitam Nutr Res Suppl. 1985;28:29-46. PMID:3009653
  2. ↑ Phillips MI, Davies DR. The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase. Biochem J. 1985 Jun 15;228(3):667-71. PMID:2992452

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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