Galactose-binding lectin
From Proteopedia
(Difference between revisions)
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<StructureSection load='1v6i' size='350' side='right' caption='Structure of peanut galactose-binding lectin tetramer complex with β-D-galactose, α-D-glucose, Ca+2 (green) and Mn+2 (purple) ions (PDB entry [[1v6i]])' scene=''> | <StructureSection load='1v6i' size='350' side='right' caption='Structure of peanut galactose-binding lectin tetramer complex with β-D-galactose, α-D-glucose, Ca+2 (green) and Mn+2 (purple) ions (PDB entry [[1v6i]])' scene=''> | ||
| + | == Function == | ||
| - | '''Galactose-binding lectin''' (GBL) is a lectin which binds the carbohydrate sequence Gal-β(1,3)-GalNac. GBL is an all beta-sheet protein. GBL is used in affinity columns for capturing proteins which are glycosylated with Gal-β(1,3)-GalNac. | + | '''Galactose-binding lectin''' (GBL) is a lectin which binds the carbohydrate sequence Gal-β(1,3)-GalNac. GBL is an all beta-sheet protein<ref>PMID:17057347</ref>. |
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| + | == Relevance == | ||
| + | |||
| + | GBL is used in affinity columns for capturing proteins which are glycosylated with Gal-β(1,3)-GalNac. | ||
</StructureSection> | </StructureSection> | ||
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**[[1l7l]], [[1uoj]] – GBL <br /> | **[[1l7l]], [[1uoj]] – GBL <br /> | ||
| - | *'' | + | *''PaGBL binary complex'' |
**[[2wyf]] – GBL + methyl-β-galactose <br /> | **[[2wyf]] – GBL + methyl-β-galactose <br /> | ||
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**[[3zyf]], [[4a6s]] – GBL + galactopyranose derivative<br /> | **[[3zyf]], [[4a6s]] – GBL + galactopyranose derivative<br /> | ||
| - | *'' | + | *''PaGBL ternary complex'' |
**[[3zyh]] – GBL + galactopyranose derivative + gal-lys-pro-leu <br /> | **[[3zyh]] – GBL + galactopyranose derivative + gal-lys-pro-leu <br /> | ||
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**[[4al9]] – GBL + α-D-galactose + α-D-glucose <br /> | **[[4al9]] – GBL + α-D-galactose + α-D-glucose <br /> | ||
| - | *'' | + | *''PaGBL quaternary complex'' |
**[[2vxj]] – GBL + β-D-galactose + α-D-galactose + α-D-glucose + β-D-glucose<br /> | **[[2vxj]] – GBL + β-D-galactose + α-D-galactose + α-D-glucose + β-D-glucose<br /> | ||
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**[[2zqo]] – LtGBL C terminal + GalNac <br /> | **[[2zqo]] – LtGBL C terminal + GalNac <br /> | ||
}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:42, 3 March 2016
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3D structures of galactose-binding lectin
Updated on 03-March-2016
References
- ↑ Natchiar SK, Srinivas O, Mitra N, Surolia A, Jayaraman N, Vijayan M. Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin. Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1413-21. Epub 2006, Oct 18. PMID:17057347 doi:10.1107/S0907444906035712
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
