Galactosidase
From Proteopedia
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| - | <StructureSection load='1kwk' size='350' side='right' caption='Beta-galactosidase complex with galactose, MPD, acetate Ca+2 (gree) and Zn+2 (grey) ions (PDB entry [[1kwk]])' scene=''> | + | <StructureSection load='1kwk' size='350' side='right' caption='Beta-galactosidase complex with galactose (stick model), MPD, acetate Ca+2 (gree) and Zn+2 (grey) ions (PDB entry [[1kwk]])' scene=''> |
== Function == | == Function == | ||
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The inherited deficiency of Agal is the cause of Fabry disease<ref>PMID:5411915</ref>. Bgal mutations causing enzyme deficiency can lead to ganglioidosis<ref>PMID:10737981</ref>. | The inherited deficiency of Agal is the cause of Fabry disease<ref>PMID:5411915</ref>. Bgal mutations causing enzyme deficiency can lead to ganglioidosis<ref>PMID:10737981</ref>. | ||
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| + | == Structural highlights == | ||
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| + | The Zn+2 binding site is composed of 4 Cys residues. The galactose binding site is seen in a large central channel<ref>PMID:12215416</ref>. | ||
== 3D Structures of Galactosidase == | == 3D Structures of Galactosidase == | ||
Revision as of 10:39, 3 March 2016
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