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Galectin

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<StructureSection load='1hlc' size='400' side='right' caption='Structure of human galectin-1 complex with lactose (PDB entry [[1hlc]])' scene=''>
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<StructureSection load='1w6o' size='400' side='right' caption='Structure of human galectin-1 complex with lactose (PDB entry [[1hlc]])' scene=''>
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== Function ==
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'''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD). GAL are known to inhibit chronic inflammation. The CRD is a beta-sandwich long enough to bind a tetrasaccharide.<br />
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'''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD)<ref>PMID:8063692</ref>. <br />
* GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br />
* GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br />
* GAL-2 is expressed primarily in gastrointestinal tract.<br />
* GAL-2 is expressed primarily in gastrointestinal tract.<br />
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* GAL-9 affects eosinophil survival. <br />
* GAL-9 affects eosinophil survival. <br />
* GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids.
* GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids.
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== Relevance ==
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GAL are known to inhibit chronic inflammation<ref>PMID:20146714</ref>. GAL-3 has a role in experimental autoimmune encephalomyelitis and melanoma methastasis<ref>PMID:22418727</ref>.
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== Structural highlights ==
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The CRD is a β-sandwich long enough to bind a tetrasaccharide.
</StructureSection>
</StructureSection>

Revision as of 11:36, 3 March 2016

Structure of human galectin-1 complex with lactose (PDB entry 1hlc)

Drag the structure with the mouse to rotate

3D structures of galectin

Updated on 03-March-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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