Glutamate racemase
From Proteopedia
(Difference between revisions)
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<StructureSection load='2jfq' size='350' side='right' caption='Structure of glutamate racemase dimer complex with D-glutamate (PDB entry [[2jfq]])' scene=''> | <StructureSection load='2jfq' size='350' side='right' caption='Structure of glutamate racemase dimer complex with D-glutamate (PDB entry [[2jfq]])' scene=''> | ||
| + | == Function == | ||
| - | '''Glutamate racemase''' (GR) catalyzes the racemization of L-glutamate to D-glutamate. GR plays a major role in bacterial cell wall biosynthesis and moonlights as gyrase inhibitor. GR inhibition is used as anti-bacterial target. | + | '''Glutamate racemase''' (GR) catalyzes the racemization of L-glutamate to D-glutamate. GR plays a major role in bacterial cell wall biosynthesis and moonlights as gyrase inhibitor<ref>PMID:18757813</ref>. |
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| + | == Relevance == | ||
| + | GR inhibition is used as anti-bacterial target. | ||
</StructureSection> | </StructureSection> | ||
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**[[2ohv]] – SpGR + D-glutamate derivative inhibitor <BR /> | **[[2ohv]] – SpGR + D-glutamate derivative inhibitor <BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:23, 8 March 2016
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3D Structures of glutamate racemase
Updated on 08-March-2016
References
- ↑ Sengupta S, Ghosh S, Nagaraja V. Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme. Microbiology. 2008 Sep;154(Pt 9):2796-803. doi: 10.1099/mic.0.2008/020933-0. PMID:18757813 doi:http://dx.doi.org/10.1099/mic.0.2008/020933-0
