Glutamate synthase
From Proteopedia
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| - | <StructureSection load='1llw' size='340' side='right' caption='Ferredoxin-dependent glutamate synthase containing a | + | <StructureSection load='1llw' size='340' side='right' caption='Ferredoxin-dependent glutamate synthase containing a Fe3S4 cluster complex with FMN, 2-oxoglutarate (PDB code [[1llw]])' scene=''> |
== Function == | == Function == | ||
'''Glutamate synthase''' (GS) is an iron-sulfur flavoprotein which catalyzes the reverse reaction which converts L-glutamine, 2-oxoglutarate and NADPH to L-glutarate and NADP. | '''Glutamate synthase''' (GS) is an iron-sulfur flavoprotein which catalyzes the reverse reaction which converts L-glutamine, 2-oxoglutarate and NADPH to L-glutarate and NADP. | ||
| - | <ref>PMID:18421771</ref>. Fd-dependent glutamate synthase catalyzes the reverse reaction converting L-glutamate and oxidized ferredoxin to L-glutamine, 2-oxoglutarate and oxidized ferredoxin<ref>PMID:6746604</ref>. Fd-GS uses FMN as a cofactor. | + | <ref>PMID:18421771</ref>. '''Fd-dependent glutamate synthase''' catalyzes the reverse reaction converting L-glutamate and oxidized ferredoxin to L-glutamine, 2-oxoglutarate and oxidized ferredoxin<ref>PMID:6746604</ref>. Fd-GS uses FMN as a cofactor. |
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== Structural highlights == | == Structural highlights == | ||
Revision as of 11:05, 9 March 2016
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3D structures of glutamate synthase
Updated on 09-March-2016
References
- ↑ Vanoni MA, Curti B. Structure-function studies of glutamate synthases: a class of self-regulated iron-sulfur flavoenzymes essential for nitrogen assimilation. IUBMB Life. 2008 May;60(5):287-300. doi: 10.1002/iub.52. PMID:18421771 doi:http://dx.doi.org/10.1002/iub.52
- ↑ Hirasawa M, Tamura G. Flavin and iron-sulfur containing ferredoxin-linked glutamate synthase from spinach leaves. J Biochem. 1984 Apr;95(4):983-94. PMID:6746604
- ↑ van den Heuvel RH, Ferrari D, Bossi RT, Ravasio S, Curti B, Vanoni MA, Florencio FJ, Mattevi A. Structural studies on the synchronization of catalytic centers in glutamate synthase. J Biol Chem. 2002 Jul 5;277(27):24579-83. Epub 2002 Apr 19. PMID:11967268 doi:10.1074/jbc.M202541200
