4zjc
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structures of the human OX1 orexin receptor bound to selective and dual antagonists== | |
| - | + | <StructureSection load='4zjc' size='340' side='right' caption='[[4zjc]], [[Resolution|resolution]] 2.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OT:[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]{(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL}METHANONE'>4OT</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zj8|4zj8]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjc OCA], [http://pdbe.org/4zjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjc RCSB], [http://www.ebi.ac.uk/pdbsum/4zjc PDBsum]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brautigam, C A]] | ||
[[Category: Clark, L]] | [[Category: Clark, L]] | ||
| + | [[Category: Coleman, P J]] | ||
| + | [[Category: Gotter, A L]] | ||
| + | [[Category: Harrell, C M]] | ||
| + | [[Category: Renger, J J]] | ||
| + | [[Category: Rosenbaum, D M]] | ||
[[Category: Shao, Z]] | [[Category: Shao, Z]] | ||
| - | [[Category: Rosenbaum, D.M]] | ||
| - | [[Category: Brautigam, C.A]] | ||
[[Category: Yin, J]] | [[Category: Yin, J]] | ||
| + | [[Category: Membrane protein-transferase complex]] | ||
| + | [[Category: Orexin]] | ||
| + | [[Category: Sb-674042]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Suvorexant]] | ||
Revision as of 03:51, 10 March 2016
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
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