Glutathione synthetase

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<StructureSection load="1glv" size="400" color="" spin="on" Scene= caption='E. coli glutathione synthetase, [[1glv]] ' >
<StructureSection load="1glv" size="400" color="" spin="on" Scene= caption='E. coli glutathione synthetase, [[1glv]] ' >
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[[Image:2hgs.png|left|200px]]
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==Function==
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'''Glutathione synthetase''' (GSS) is an ATP-dependent enzyme which catalyzes the condensation of γ-glutamylcysteine and glycine to glutathione. GSS is part of the glutathione biosynthesis pathway.
'''Glutathione synthetase''' (GSS) is an ATP-dependent enzyme which catalyzes the condensation of γ-glutamylcysteine and glycine to glutathione. GSS is part of the glutathione biosynthesis pathway.
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This enzyme's action produces glutathione, a vital and abundant tripeptide that is found in most living cells. In humans, mutations to hGS can lead to lowered levels of glutathione, causing a range of disease states. Lowered levels of glutathione have been associated with diseases such as human immunodeficiency, hepatitis C, type II diabetes, ulcerative colitis, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, and cataracts.
This enzyme's action produces glutathione, a vital and abundant tripeptide that is found in most living cells. In humans, mutations to hGS can lead to lowered levels of glutathione, causing a range of disease states. Lowered levels of glutathione have been associated with diseases such as human immunodeficiency, hepatitis C, type II diabetes, ulcerative colitis, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, and cataracts.
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===Common Mutations<ref>PMID:10369661</ref>===
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==Common Mutations<ref>PMID:10369661</ref>==
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Revision as of 11:29, 10 March 2016

E. coli glutathione synthetase, 1glv

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Reference

  1. ↑ Dinescu A, Cundari TR, Bhansali VS, Luo JL, Anderson ME. Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes. J Biol Chem. 2004 May 21;279(21):22412-21. Epub 2004 Feb 27. PMID:14990577 doi:10.1074/jbc.M401334200
  2. ↑ Polekhina G, Board PG, Gali RR, Rossjohn J, Parker MW. Molecular basis of glutathione synthetase deficiency and a rare gene permutation event. EMBO J. 1999 Jun 15;18(12):3204-13. PMID:10369661 doi:10.1093/emboj/18.12.3204


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