Glutamate dehydrogenase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The biological assembly of GLDH from ''Clostridium symbiosum'' is <scene name='49/490918/Cv/5'>homohexamer | + | The biological assembly of GLDH from ''Clostridium symbiosum'' is <scene name='49/490918/Cv/5'>homohexamer</scene>. The <scene name='49/490918/Cv/2'>glutamate binding pocket of GLDH</scene> is in a cleft between the two domains of the enzyme with <scene name='49/490918/Cv/4'>residue D165 serving as a general base and a protein-bound water molecule as the attacking nucleophile</scene> <ref>PMID:8263917</ref>. Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
==3D structures of glutamate dehydrogenase== | ==3D structures of glutamate dehydrogenase== | ||
Revision as of 09:22, 13 March 2016
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3D structures of glutamate dehydrogenase
Updated on 13-March-2016
References
- ↑ FRIEDEN C. GLUTAMATE DEHYDROGENASE. VI. SURVEY OF PURINE NUCLEOTIDE AND OTHER EFFECTS ON THE ENZYME FROM VARIOUS SOURCES. J Biol Chem. 1965 May;240:2028-35. PMID:14299621
- ↑ Smith TJ, Schmidt T, Fang J, Wu J, Siuzdak G, Stanley CA. The structure of apo human glutamate dehydrogenase details subunit communication and allostery. J Mol Biol. 2002 May 3;318(3):765-77. PMID:12054821 doi:10.1016/S0022-2836(02)00161-4
- ↑ Yorifuji T, Muroi J, Uematsu A, Hiramatsu H, Momoi T. Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics. Hum Genet. 1999 Jun;104(6):476-9. PMID:10453735
- ↑ Stillman TJ, Baker PJ, Britton KL, Rice DW. Conformational flexibility in glutamate dehydrogenase. Role of water in substrate recognition and catalysis. J Mol Biol. 1993 Dec 20;234(4):1131-9. PMID:8263917 doi:http://dx.doi.org/10.1006/jmbi.1993.1665
