Glycosyltransferase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_1cxh| PDB=1cxh | SIZE=350| SCENE= |right|CAPTION=Cyclodextrin glycosyltransferase complex with substrate maltoheptaose and Ca+2 ion, [[1cxh]] }}
{{STRUCTURE_1cxh| PDB=1cxh | SIZE=350| SCENE= |right|CAPTION=Cyclodextrin glycosyltransferase complex with substrate maltoheptaose and Ca+2 ion, [[1cxh]] }}
 +
== Function ==
 +
'''Glycosyltransferase''' (GT) are enzymes which catalyze the transfer of monosaccharide to alcohol, carbohydrate, protein or inorganic phosphate<ref>PMID:18990828</ref>. <br />
 +
'''Galactosyltransferase''' (AGT) is a GT which catalyzes the transfer of galactose during the synthesis of polysaccharides<ref>PMID:18393823</ref>.<br />
 +
'''Fucosylglycoprotein 3-AGT''' (GTB) or '''histo-blood group ABO system transferase''' is the basis of the blood ABO system. It involves 3 carbohydrate antigens: A, B and H. <br />
 +
'''Flavonoid GT''' glycosylates flavonoids<ref>PMID:23144555</ref>. For details on flavonoid GT see [[Vitis vinifera Flavonoid 3-O-Glucosyltransferase (Vv3GT)]].
-
'''Glycosyltransferase''' (GT) are enzymes which catalyze the transfer of monosaccharide to alcohol, carbohydrate, protein or inorganic phosphate. '''Galactosyltransferase''' (AGT) is a GT which catalyzes the transfer of galactose during the synthesis of polysaccharides. '''Fucosylglycoprotein 3-AGT''' (GTB) or '''histo-blood group ABO system transferase''' is the basis of the blood ABO system. It involves 3 carbohydrate antigens: A, B and H. Individuals with blood type A, B and AB has glycosyltransferase activitiy which converts antigen H to A or B. Individuals with blood type O lack this activity. For details see [[Human ABO(H) Blood Group Glycosyltransferases]].<br />
+
== Relevance ==
-
For details on '''flavonoid GT''' see [[Vitis vinifera Flavonoid 3-O-Glucosyltransferase (Vv3GT)]].
+
Individuals with blood type A, B and AB has glycosyltransferase activitiy which converts antigen H to A or B. Individuals with blood type O lack this activity. For details see [[Human ABO(H) Blood Group Glycosyltransferases]].<br />
==3D structures of glycosyltransferase==
==3D structures of glycosyltransferase==
Line 248: Line 253:
**[[1zi3]] - hAGT catalytic domain + acetylactosamine
**[[1zi3]] - hAGT catalytic domain + acetylactosamine
}}
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:55, 15 March 2016

Template:STRUCTURE 1cxh

Contents

Function

Glycosyltransferase (GT) are enzymes which catalyze the transfer of monosaccharide to alcohol, carbohydrate, protein or inorganic phosphate[1].
Galactosyltransferase (AGT) is a GT which catalyzes the transfer of galactose during the synthesis of polysaccharides[2].
Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase is the basis of the blood ABO system. It involves 3 carbohydrate antigens: A, B and H.
Flavonoid GT glycosylates flavonoids[3]. For details on flavonoid GT see Vitis vinifera Flavonoid 3-O-Glucosyltransferase (Vv3GT).

Relevance

Individuals with blood type A, B and AB has glycosyltransferase activitiy which converts antigen H to A or B. Individuals with blood type O lack this activity. For details see Human ABO(H) Blood Group Glycosyltransferases.

3D structures of glycosyltransferase

Updated on 15-March-2016

References

  1. ↑ Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Adv Enzymol Relat Areas Mol Biol. 2009;76:55-119. PMID:18990828
  2. ↑ Qasba PK, Ramakrishnan B, Boeggeman E. Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets. 2008 Apr;9(4):292-309. PMID:18393823
  3. ↑ Jadhav SK, Patel KA, Dholakia BB, Khan BM. Structural characterization of a flavonoid glycosyltransferase from Withania somnifera. Bioinformation. 2012;8(19):943-9. doi: 10.6026/97320630008943. Epub 2012 Oct 1. PMID:23144555 doi:http://dx.doi.org/10.6026/97320630008943

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Glycosyltransferase"
Personal tools