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GTP-binding protein
From Proteopedia
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<scene name='Template:GPCR3sn6/3sn6memrane/15'>An activated G protein-coupled receptor</scene> (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) ([[3sn6]]), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green. | <scene name='Template:GPCR3sn6/3sn6memrane/15'>An activated G protein-coupled receptor</scene> (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) ([[3sn6]]), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green. | ||
| + | == Disease == | ||
| + | Mutations in heterotrimeric α subunit were identified in endocrine tumors and in McCune-Albright syndrome<ref>PMID:11720871</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
''E. coli'' small GTPase ERA binds GDP in a cavity formed by 3 highly conserved regions<ref>PMID:19706445</ref>. | ''E. coli'' small GTPase ERA binds GDP in a cavity formed by 3 highly conserved regions<ref>PMID:19706445</ref>. | ||
Revision as of 10:06, 17 March 2016
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3D Structures of GTP-binding protein
Updated on 17-March-2016
See GTPase-HRAS
See Also
References
- ↑ Preininger AM, Hamm HE. G protein signaling: insights from new structures. Sci STKE. 2004 Jan 27;2004(218):re3. PMID:14762218 doi:http://dx.doi.org/10.1126/stke.2182004re3
- ↑ Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153-208. PMID:11152757
- ↑ Lania A, Mantovani G, Spada A. G protein mutations in endocrine diseases. Eur J Endocrinol. 2001 Nov;145(5):543-59. PMID:11720871
- ↑ Tu C, Zhou X, Tropea JE, Austin BP, Waugh DS, Court DL, Ji X. Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14843-8. Epub 2009 Aug 17. PMID:19706445
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