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User:John S. de Banzie/Sandbox 4

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==Yeast U4/U6.U5 tri-snRNP==
==Yeast U4/U6.U5 tri-snRNP==
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<StructureSection load='5gan' size='640' side='right' caption='U4/U6.U5 snRNP' scene=''>
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<StructureSection load='5gan' size='640' side='right' caption='U4/U6.U5 snRNP' [[5gan]]' scene='72/726441/Firstscene/2'>
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Protein is shown in white, RNA in red.
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The <scene name='72/726441/Firstscene/2'>initial view</scene> shows proteins in white and the three snRNAs in colour (U4: orange, U5: red, and U6: purple).
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For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>.
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Focusing <scene name='72/726441/Rnascene/1'>on the RNAs</scene> reveals secondary structure and extensive base pairing between the U4 and U6 snRNAs.
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The spliceosome is assembled from the U4/U6.U5 tri-snRNP, the U1 snRNP, and the U2 snRNP. The U2 snRNP interacts with the region highlighted in blue <scene name='72/726441/Dockscene/1'>in this view</scene>. The U1 snRNP interacts with the U2 snRNP. The initial assembly is inactive; extensive conformational changes (including unwinding of the U4/U6 base pairing) are required for activation of the spliceosome.
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For the source article see Nguyen et al, 2016<ref>DOI 10.1038/nature16940</ref>.
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Yeast U4/U6.U5 tri-snRNP

U4/U6.U5 snRNP

Drag the structure with the mouse to rotate

References

  1. ↑ Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K. Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution. Nature. 2016 Feb 18;530(7590):298-302. doi: 10.1038/nature16940. Epub 2016 Feb 1. PMID:26829225 doi:http://dx.doi.org/10.1038/nature16940

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John S. de Banzie

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