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===Na+ Binding Pocket=== | ===Na+ Binding Pocket=== | ||
| - | W321, which is positioned at the bottom of the hydrophobic pocket(green link from allie), sets the top of the Na+ | + | W321, which is positioned at the bottom of the hydrophobic pocket(green link from allie), sets the top of the <scene name='72/721548/Na_bind_pocket/12'>Na+ Binding Pocket</scene>. The Na+ ion binding pocket acts as a negative allosteric site for G protein activity. When Na+ enters the Na+ ion binding pocket, it interacts with Asp 113, and shuts down the activity of the protein. When the G protein is in its active state, the Na+ ion binding pocket is collapsed, preventing the entrance of Na+. |
| - | + | ||
== Function == | == Function == | ||
Revision as of 19:13, 25 March 2016
NTSR1-ELF, Rattus norvegicus
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
