HypA-HypB-HypC-HypD-HypE-HypF
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='2z1d' size='340' side='right' caption='HypD with Fe4S4 center (PDB code 2z1d)' scene=''> The [NiFe] hydrogenase contains a NiFe(CO)(CN)2 in its reaction center...) |
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<StructureSection load='2z1d' size='340' side='right' caption='HypD with Fe4S4 center (PDB code [[2z1d]])' scene=''> | <StructureSection load='2z1d' size='340' side='right' caption='HypD with Fe4S4 center (PDB code [[2z1d]])' scene=''> | ||
| - | The [NiFe] hydrogenase contains a NiFe(CO)(CN)2 in its reaction center. '''HypA, HypB, HypC, HypD, HypE and HypF''' are required for the maturation of [NiFe] hydrogenase. '''HypA''' and '''HypB''' are involved in the insertion of Ni atom. '''HypE''' and '''HypF''' catalyze the biosynthesis of the CN ligand. '''HypC''' and '''HypD''' deliver the Fe and CO to the hydrogenase active center. For more details of HypA see [[Molecular Playground/HypA]]. | ||
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== Function == | == Function == | ||
| + | The [NiFe] hydrogenase contains a NiFe(CO)(CN)2 in its reaction center. '''HypA, HypB, HypC, HypD, HypE and HypF''' are required for the maturation of [NiFe] hydrogenase. '''HypA'''<ref>PMID:15595183</ref> and '''HypB'''<ref>PMID:9140970</ref> are involved in the insertion of Ni atom. '''HypE''' and '''HypF'''<ref>PMID:15291820</ref> catalyze the biosynthesis of the CN ligand. '''HypC''' and '''HypD'''<ref>PMID:15504408</ref> deliver the Fe and CO to the hydrogenase active center. For more details of HypA see [[Molecular Playground/HypA]]. | ||
== Disease == | == Disease == | ||
Revision as of 10:17, 27 March 2016
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3D Structures of HypA, HypB, HypC, HypD, HypE and HypF
Updated on 27-March-2016
References
- ↑ Erickson BE. RNA enzyme reactions on a chip. Anal Chem. 2004 Dec 1;76(23):426A. PMID:15595183
- ↑ Olson JW, Fu C, Maier RJ. The HypB protein from Bradyrhizobium japonicum can store nickel and is required for the nickel-dependent transcriptional regulation of hydrogenase. Mol Microbiol. 1997 Apr;24(1):119-28. PMID:9140970
- ↑ Blokesch M, Paschos A, Bauer A, Reissmann S, Drapal N, Bock A. Analysis of the transcarbamoylation-dehydration reaction catalyzed by the hydrogenase maturation proteins HypF and HypE. Eur J Biochem. 2004 Aug;271(16):3428-36. PMID:15291820 doi:http://dx.doi.org/10.1111/j.1432-1033.2004.04280.x
- ↑ Blokesch M, Albracht SP, Matzanke BF, Drapal NM, Jacobi A, Bock A. The complex between hydrogenase-maturation proteins HypC and HypD is an intermediate in the supply of cyanide to the active site iron of [NiFe]-hydrogenases. J Mol Biol. 2004 Nov 12;344(1):155-67. PMID:15504408 doi:http://dx.doi.org/10.1016/j.jmb.2004.09.040
