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User:Daniel Schemenauer/Sandbox 1
From Proteopedia
(Difference between revisions)
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== Structure == | == Structure == | ||
=== Overall Stucture === | === Overall Stucture === | ||
| - | = | + | mGlu<sub>5</sub> is seen as a [https://en.wikipedia.org/wiki/Protein_dimer homodimer] ‘in vivo’, with each subunit comprising three domains; extracellular, trans-membrane and intracellular. The structures shown here are centered on the trans-membrane domain, comprised of seven α-helices all roughly parallel to one another <ref name="Primary">PMID: 25042998 </ref>. |
<scene name='72/726409/Ionic_lock2/1'>Ionic Lock K665,E770</scene> | <scene name='72/726409/Ionic_lock2/1'>Ionic Lock K665,E770</scene> | ||
<scene name='72/726409/Hydrogen_bond_614-668/1'>Hydrogen Bond S614,A668</scene> | <scene name='72/726409/Hydrogen_bond_614-668/1'>Hydrogen Bond S614,A668</scene> | ||
Revision as of 19:55, 27 March 2016
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References
- ↑ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA. The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8. Epub 2003 Apr 4. PMID:12679517 doi:http://dx.doi.org/10.1073/pnas.0230374100
- ↑ 2.0 2.1 Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM. Molecular signatures of G-protein-coupled receptors. Nature. 2013 Feb 14;494(7436):185-94. doi: 10.1038/nature11896. PMID:23407534 doi:http://dx.doi.org/10.1038/nature11896
- ↑ Pin JP, Galvez T, Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther. 2003 Jun;98(3):325-54. PMID:12782243
- ↑ 4.0 4.1 Dore AS, Okrasa K, Patel JC, Serrano-Vega M, Bennett K, Cooke RM, Errey JC, Jazayeri A, Khan S, Tehan B, Weir M, Wiggin GR, Marshall FH. Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature. 2014 Jul 31;511(7511):557-62. doi: 10.1038/nature13396. Epub 2014 Jul 6. PMID:25042998 doi:http://dx.doi.org/10.1038/nature13396
