Integrin
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
==Disease == | ==Disease == | ||
Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>. | Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis<ref>PMID:8976799</ref>. Defective integrin is involved in periodontal diseases<ref>PMID:24662197</ref>. | ||
| + | |||
| + | == Structural highlights == | ||
| + | The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:21, 29 March 2016
| |||||||||||
3D structures of integrin
Updated on 29-March-2016
References
- ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
- ↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
- ↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010
- ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
